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Registration Dossier
Diss Factsheets
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EC number: 210-852-7 | CAS number: 624-54-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
In a non-GLP study conducted following methodology equivalent to OECD TG 404, the mean erythema and edema scores over New Zealand White 6 rabbits exposed to 0.5 ml of pentyl propionate was 0, i.e. no signs of erythema and edema were noted in any of the exposed animals.
In a non-GLP study conducted following methodology equivalent to OECD TG 405, the mean corneal, iris, chemosis and conjunctival scores over 6 New Zealand White rabbits exposed to 0.1 ml of pentyl propionate was 0, i.e. no signs of eye irritation were noted in any of the exposed animals.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study methodology followed was according to OECD TG 404 and the report contains sufficient information to permit a meaningful evaluation of study results
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: in-house
- Age at study initiation: adults
- Weight at study initiation: 2.0-3.0 kg
- Housing: group housed
- Diet (e.g. ad libitum): appropriate commercial diet, ad libitum
- Water (e.g. ad libitum): municipal water, ad libitum - Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped intact skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml undiluted UCAR n-pentyl propionate
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- one hour, 1 day, 2 days, 3 days and 7 days
- Number of animals:
- 3 male + 3 female rabbits
- Details on study design:
- New Zealand White rabbits were dosed topically with 0.5 ml of UCAR n-pentyl propionate to the clipped intact skin of the trunk under a gauze patch and loosely covered with impervious sheeting. The animals were restrained for the 4-hour contact period. Excess samples were removed after the contact period and skin reactions were scored by Draize method at 1 hour, 1 day, 2 days, 3 days and 7 days with perios extended upto 14 days depending on the skin recations noted.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- over 6 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- over 6 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- No signs of erythema and edema were noted in any of the exposed animals
- Other effects:
- One female rabbit was found dead on day 7 with no apparent signs of irritation, concluded to be not treatment related
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the study, UCAR n-pentyl propionate would not be be classified as a skin irritant according to the Guidance to Regulation (EC) No. 1272/2008 on Classification, Labelling and Packaging of substances and mixtures
- Executive summary:
In this study, the skin irritation potential of undiluted UCAR n-pentyl propionate was evaluated on three male and three female New Zealand White rabbits over a 4 hour contact period. The animals were dosed topically with 0.5 ml of UCAR n-pentyl propionate to the clipped intact skin of the trunk under a gauze patch and loosely covered with impervious sheeting. The animals were restrained for the 4-hour contact period. Excess samples were removed after the contact period and skin reactions were scored by Draize method at 1 hour, 1 day, 2 days, 3 days and 7 days with perios extended upto 14 days depending on the skin recations noted. No signs of erythema and edema were noted in any of the exposed animals. One female rabbit was found dead on day 7 with no apparent signs of irritation, concluded to be not treatment related. Under the conditions of the study, UCAR n-pentyl propionate would not be be classified as a skin irritant according to the Guidance to Regulation (EC) No. 1272/2008 on Classification, Labelling and Packaging of substances and mixtures.
Reference
None
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study methodology followed was equivalent to OECD TG 405 and the report contains sufficient information to permit a meaningful evaluation of study results
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: in-house
- Age at study initiation: adults
- Weight at study initiation: 2.0-3.0 kg
- Housing: group housed
- Diet (e.g. ad libitum): appropriate commercial diet, ad libitum
- Water (e.g. ad libitum): municipal water, ad libitum - Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.1 ml undiluted UCAR n-pentyl propionate
- Duration of treatment / exposure:
- approximately one second
- Observation period (in vivo):
- 1 hour, approximately 4 hours, 1 day, 2 days, 3 days and 7 days with additional readings on 14 days and 21 days, if needed
- Number of animals or in vitro replicates:
- 4 male + 2 female
- Details on study design:
- 0.1 ml of UCAR n-pentyl propionate (undiluted) was instilled into the lower conjunctival sac of one eye of 6 New Zealand White rabbits and the eyelids held together about 1 second. The eyes were scored as per Draize method at 1 hour, 4 hours, 1 day, 2 days, 3 days and 7 days after dosing. Additional readings were done on days 14 and 21, if needed. Fluorescein (2%) staining was used to determine corneal injury before dosing and at readings after one day.
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- over 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- over 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- over 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- over 6 rabbits
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- There were no signs of eye irritation in the tested rabbits
- Other effects:
- not applicable
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of the study, UCAR n-pentyl propionate would not be be classified as an eye irritant according to the Guidance to Regulation (EC) No. 1272/2008 on Classification, Labelling and Packaging of substances and mixtures
- Executive summary:
In this study, the eye irritation potential of undiluted UCAR n-pentyl propionate was evaluated on four male and two female New Zealand White rabbits.
0.1 ml of UCAR n-pentyl propionate (undiluted) was instilled into the lower conjunctival sac of one eye of 6 New Zealand White rabbits and the eyelids held together about 1 second. The eyes were scored as per Draize method at 1 hour, 4 hours, 1 day, 2 days, 3 days and 7 days after dosing. Additional readings were done on days 14 and 21, if needed. Fluorescein (2%) staining was used to determine corneal injury before dosing and at readings after one day. There were no signs of eye irritation in the tested rabbits. Under the conditions of the study, UCAR n-pentyl propionate would not be be classified as an eye irritant according to the Guidance to Regulation (EC) No. 1272/2008 on Classification, Labelling and Packaging of substances and mixtures.
Reference
None
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation -
In a non-GLP study conducted following methodology equivalent to OECD TG 404, the mean erythema and edema scores over 6 New Zealand White rabbits exposed to 0.5 ml of pentyl propionate was 0, i.e. no signs of erythema and edema were noted in any of the exposed animals.
Eye irritation -
In a non-GLP study conducted following methodology equivalent to OECD TG 405, the mean corneal, iris, chemosis and conjunctival scores over 6 New Zealand White rabbits exposed to 0.1 ml of pentyl propionate was 0, i.e. no signs of eye irritation were noted in any of the exposed animals.
Respiratory irritation -
The key studies for repeated dose toxicity indicate that irritation of the upper respiratory tract at high concentrations occurs. However the data are not sufficient to lead to a conclusion for classification. In addition, no reports of upper respiratory tract or respiratory irritation have been reported from workers handling the material.
Justification for classification or non-classification
In the absence of any skin, eye or respiratory irritation and based on the Guidance to Regulation (EC) No. 1272/2008 on Classification, Labelling and Packaging of substances and mixtures, pentyl propionate will not be classified as a skin or an eye or a respiratory irritant.
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