Pentyl propionate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1988

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study methodology followed was equivalent to OECD TG 403 and the report contains sufficient information to permit a meaningful evaluation of study results

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

not specified

Principles of method if other than guideline:

not applicable

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Pentyl propionate

EC Number:

210-852-7

EC Name:

Pentyl propionate

Cas Number:

624-54-4

Molecular formula:

C8H16O2

IUPAC Name:

pentyl propanoate

Details on test material:

- Name of test material (as cited in study report): UCAR N-pentyl propionate
- Molecular weight: 144.2
- Physical state: clear colourless, low viscosity liquid
- Analytical purity: 99+ %
- Impurities (identity and concentrations): < 1%
- Lot/batch No.: BRRC Sample No. 51-19
- Storage condition of test material: at room temperature

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: in-house
- Age at study initiation: adults
- Weight at study initiation: 200-300 grams
- Fasting period before study: overnight fasting before dosing
- Housing: group housed
- Diet (e.g. ad libitum): commercial diet, ad libitum
- Water (e.g. ad libitum): municipal water, ad libitum

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

whole body

Vehicle:

not specified

Details on inhalation exposure:

Sprague-Dawley rats were exposed to substantially saturated vapor for 6 hours. The vapor was produced by enclosing approximately 100 grams of the test material in a sealed 100-151 liter animal chamber for approximately 18 hours (static conditions). A mixing fan was used to periodically agitate the chamber atmosphere to aid in distribution of the vapor. Oxygen was added as needed to maintain a chamber oxygen content of approximately 20%.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

6 h

Concentrations:

substantially saturated vapor concentration

No. of animals per sex per dose:

5 males + 5 females

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily and weights recorded weekly
- Necropsy of survivors performed: yes

Statistics:

LD50 and the estimated LD50 slopes were calculated by the moving average method

Results and discussion

Preliminary study:

not applicable

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

> 10.07 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

6 h

Remarks on result:

other: Conversion of a substantially saturated vapor exposure to mg/l

Mortality:

None noted

Clinical signs:

other: None noted

Body weight:

Body weight noted in all the animals of the treated group

Gross pathology:

No gross pathological changes attributable to exposure were noted

Other findings:

not applicable

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Under the conditions of the study, no mortality was noted in Sprague Dawley rats exposed to substantially saturated vapor levels of UCAR n-pentyl propionate (LC0 greater than 10.07 mg/l; converted value) and would not be classified as per Guidance to Regulation (EC) No. 1272/2008 on Classification, Labelling and Packaging of substances and mixtures.

Executive summary:

In this study, groups of 5 male and 5 female Sprague Dawley rats (adults, weighing between 200 -300 grams) were exposed to substantially saturated vapors of UCAR n-pentyl propionate for 6 hours. The vapor was produced by enclosing approximately 100 grams of the test material in a sealed 100-151 liter animal chamber for approximately 18 hours (static conditions). A mixing fan was used to periodically agitate the chamber atmosphere to aid in distribution of the vapor. Oxygen was added as needed to maintain a chamber oxygen content of approximately 20%. There were no mortalities, clinical signs of toxicity and gross pathological signs noted at the end of the study. Body weight gain was noted in all the exposed animals. Under the conditions of the study, no mortality was noted in Sprague Dawley rats exposed to substantially saturated vapor levels of UCAR n-pentyl propionate (LC0 greater than 10.07 mg/l; converted value) and would not be classified as per Guidance to Regulation (EC) No. 1272/2008 on Classification, Labelling and Packaging of substances and mixtures.