Registration Dossier
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Diss Factsheets
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EC number: 210-852-7 | CAS number: 624-54-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to EPA-ASTM procedures and the report contains sufficient information to permit a meaningful evaluation of study results
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- other: EPA-ASTM guidelines
- Deviations:
- not specified
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
not applicable - Analytical monitoring:
- no
- Details on sampling:
- no data
- Vehicle:
- no
- Details on test solutions:
- no data
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- TEST ORGANISM
- Common name: fathead minnows
- Source: in-house
- Length at study initiation: size of the minnows ranged from 1.5-3.0 cm
ACCLIMATION
- Health during acclimation (any mortality observed): no information. Any chemical treatment required to control or prevent disease was stopped at least 5 days prior to testing - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- not applicable
- Hardness:
- 40-60 mg/l as CaCO3
- Test temperature:
- no data available
- pH:
- no data available
- Dissolved oxygen:
- Minimal aeration was supplied when dissolved oxygen was below about 4 mg/l
- Salinity:
- not applicable
- Nominal and measured concentrations:
- no data
- Details on test conditions:
- The definitive test was conducted by EPA-ASTM procedures using 10 fathead minnows per test concentration in a total volume of 0.75 liters. Replicates were usually prepared. Temperature, fish survival, pH and dissolved oxygen levels were monitored during the test period of 96 hours. Minimal aeration was supplied when the dissolved oxygen was below about 4 mg/l.
Dechlorinated Charleston municipal water was used in tests as dilution water and in experimental controls and the same water was used for maintaining the fathead minnow population in-house. The incoming water was treated with activated carbon in two gallon filter yielding a chlorine-free dilution water with a pH very close to 7.0. Total hardness of the water measured 40-60 mg/l as CaCO3. The carbon beds were changed as needed to maintain water quality. - Reference substance (positive control):
- not specified
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 55.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 43.2-72.0 mg/l
- Details on results:
- No data
- Results with reference substance (positive control):
- not applicable
- Reported statistics and error estimates:
- no data
- Sublethal observations / clinical signs:
None
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Under the conditions of the study, the 96-hour LC50 of n-pentyl propionate to fathead minnows is 55.9 mg/l with 95% confidence limits ranging between 43.2 - 72.0 mg/l.
- Executive summary:
The definitive test was conducted by EPA-ASTM procedures using 10 fathead minnows per test concentration in a total volume of 0.75 liters. Replicates were usually prepared. Temperature, fish survival, pH and dissolved oxygen levels were monitored during the test period of 96 hours. Minimal aeration was supplied when the dissolved oxygen was below about 4 mg/l. Dechlorinated Charleston municipal water was used in tests as dilution water and in experimental controls and the same water was used for maintaining the fathead minnow population in-house. The incoming water was treated with activated carbon in two gallon filter yielding a chlorine-free dilution water with a pH very close to 7.0. Total hardness of the water measured 40-60 mg/l as CaCO3. The carbon beds were changed as needed to maintain water quality.
Under the conditions of the study, the 96-hour LC50 of n-pentyl propionate to fathead minnows is 55.9 mg/l with 95% confidence limits ranging between 43.2 - 72.0 mg/l.
Reference
Description of key information
In a GLP study conducted following EPA-ASTM guidelines, the 96-hour LC50 of n-pentyl propionate was reported as 55.9 mg/l with 95% fiducial limits ranging between 43.2 - 72.0 mg/l
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 55.9 mg/L
Additional information
In a GLP study conducted following EPA-ASTM guidelines and rated a Klimisch score of 2, the 96-hour LC50 of n-pentyl propionate to fathead minnows (Pimephales promelas) was reported as 55.9 mg/l with 95% fiducial limits ranging between 43.2 - 72.0 mg/l.
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