Registration Dossier
Registration Dossier
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EC number: 210-852-7 | CAS number: 624-54-4
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.041 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.411 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.004 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 3.63 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 1.24 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.124 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.224 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
In a GLP study conducted according to OECD TG 301F (Manometric Respirometry Test), biodegradation of pentyl propionate began soon after addition to the test mixtures, and after 28 days reached 90.1 ± 6.5% (mean ± 1 SD) based on biological oxygen demand (BOD) and exceeded 60% biodegradation within 5.9 days of the start of the test and within the 10-day window detailed in OECD 301F. The results of this test demonstrated that Pentyl Propionate can be classified as “readily biodegradable”, according to the OECD 301F: Manometric Respirometry Test.
In a GLP study conducted as per EPA-ASTM guidelines, the 96-hour LC50 of n-pentyl propionate to fathead minnows (Pimephales promelas) was 55.9 mg/l with 95% fiducial limits ranging between 43.2 - 72.0 mg/l.
In a GLP study conducted as per the methods laid out in the EPA Committee on Methods for Toxicity Tests with Aquatic Organisms, the 48-hour LC50 of pentyl propionate to Daphnia magna is 60 mg/l with 95% fiducial limits ranging between 50.6 - 71.2 mg/l.
In a GLP study conducted as per OECD TG 201, the 96-hour ErC50 (growth rate) of pentyl propionate to Selenastrum capricornutum was 41.7 mg/l with 95% fiducial limits renging between 40.3 - 44.2 mg/l and the 96-hour NOEC was 4.5 mg/l.
Based on this information and based on the Guidance to Regulation (EC) No. 1272/2008 on Classification, Labelling and Packaging of substances and mixtures, pentyl propionate will not be classified for aquatic toxicity (acute and chronic).
Conclusion on classification
In a GLP study conducted according to OECD TG 301F (Manometric Respirometry Test), biodegradation of pentyl propionate began soon after addition to the test mixtures, and after 28 days reached 90.1 ± 6.5% (mean ± 1 SD) based on biological oxygen demand (BOD) and exceeded 60% biodegradation within 5.9 days of the start of the test and within the 10-day window detailed in OECD 301F. The results of this test demonstrated that Pentyl Propionate can be classified as “readily biodegradable”, according to the OECD 301F: Manometric Respirometry Test.
In a GLP study conducted as per EPA-ASTM guidelines, the 96-hour LC50 of n-pentyl propionate to fathead minnows (Pimephales promelas) was 55.9 mg/l with 95% fiducial limits ranging between 43.2 - 72.0 mg/l.
In a GLP study conducted as per the methods laid out in the EPA Committee on Methods for Toxicity Tests with Aquatic Organisms, the 48-hour LC50 of pentyl propionate to Daphnia magna is 60 mg/l with 95% fiducial limits ranging between 50.6 - 71.2 mg/l.
In a GLP study conducted as per OECD TG 201, the 96-hour ErC50 (growth rate) of pentyl propionate to Selenastrum capricornutum was 41.7 mg/l with 95% fiducial limits renging between 40.3 - 44.2 mg/l and the 96-hour NOEC was 4.5 mg/l.
Based on this information and based on the Guidance to Regulation (EC) No. 1272/2008 on Classification, Labelling and Packaging of substances and mixtures, pentyl propionate will not be classified for aquatic toxicity (acute and chronic).
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