Registration Dossier
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EC number: 241-867-7 | CAS number: 17928-28-8
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
(60 d post hatch) NOEC ≥7.9 µg/l (time weighted mean measured) (highest concentration tested) (OECD 210), based on hatching, larval survival, abnormal appearance and behaviour in Oncorhynchus mykiss, read-across
Key value for chemical safety assessment
Additional information
No data are available with the registered substance.
A 60-day post-hatch NOEC of ≥7.9 µg/l (time weighted mean measured) has been determined for the effects of the analogous substance, decamethyltetrasiloxane (CAS 141-62-8) on hatching, larval survival, abnormal appearance and behaviour in Oncorhynchus mykiss in the fish early-life stage test (OECD 210). In view of the exposure regime it is likely that the test organisms were exposed primarily to the tested substance rather than its degradation products.
Supporting evidence is provided by mortality data in a bioconcentration study. However, a 35-day LC50 value of >6.7 μg/l (nominal), >5.3 μg/l (mean measured) and NOEC of ≥6.7 μg/l (nominal), ≥5.3 μg/l (mean measured) have been determined for the effects of the closely related substance L4 (CAS 141-62-8) on mortality of Pimephales promelas.
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