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EC number: 941-303-6 | CAS number: 1689576-55-3
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Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Calculated BCF is in the range: 4.54 ÷ 8.22
Key value for chemical safety assessment
- BCF (aquatic species):
- 5.6 L/kg ww
Additional information
The bioconcentration factor of ‘Esterification products of 1,3-dioxo-2-benzofuran-5-carboxylic acid with nonan-1-ol’, calculated using the software tool T.E.S.T. v4.2.1 and applying the Consensus method, is in the following range: BCF= 4.54 ÷ 8.22
The key value is within the estimation range of the predicted BCFs of the 15 principal components of the assessed UVCB substance, showing that the potential for bioaccumulation is low.
This is supported by experimental data from a structural analogue of the registered substance - a trimellitate ester with C8 branched alcohol side chains. A measured BCF of up to 2.7 suggests the potential for bioconcentration in aquatic organisms is low. However, there are some uncertainties in the experimental data mainly due to testing at concentrations above the water solubility of the substance by the use of solubilising agents which are recognised as having the potential to lead to an underestimation of the BCF.
Information for the potential of a substance to bioaccumulate within aquatic organisms may be obtained from toxicokinetic studies with mammals, the available information on the trimellitates indicating that the parent substance is poorly absorbed. (Q)SPR modelling suggests that dermal absorption is expected to be negligible (see Section 7.1.2). Studies in the rat (see Section 7.1.1) indicate that, following oral administration, the substance is partially hydrolysed in the gastro-intestinal tract to the corresponding di-ester and free alcohol and, following further hydrolysis, the mono-ester. Only the alcohol and mono-ester appear to be absorbed with the majority of the administered dose eliminated unchanged in the faeces. Once absorbed, elimination is rapid suggesting that accumulation, particularly in higher trophic organisms, may be low. These considerations suggest that the potential for bioaccumulation is low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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