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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1983
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
GLP compliance:
yes
Analytical monitoring:
no
Buffers:
pH4: 0.05 M Potassium hydrogenphtalate
pH7: 0.041 M Na2HPO4 + 0.028 M KH2PO4
pH9: 0.043 M Na2B4O7 + 0.017 M KH2PO4
Details on test conditions:
Preparation of the test solution:
Pipette 2.00 ml of the solution under study in a 10 ml graduated flask, add 3.0 ml distilled water and fill up to the mark at room temperature with methanol.

Apparatus and conditions:
- Apparatus: Liquid chromatograph
- Column: Nucleosil C 18-10 µm (300 X 4 mm)
- Column temperature: room temperature
- Mobile phase: methanol + water (90 + 10 vol. %)
- Injection volume: 50.0 µl
- Flow rate: 1.00 ml/min
- Analysis time: ca 6 min
- Retention time of the test substance: 4.9 min
Duration:
5 d
pH:
4
Temp.:
50 °C
Duration:
5 d
pH:
7
Temp.:
50 °C
Duration:
5 d
pH:
9
Temp.:
50 °C
Transformation products:
no
pH:
4
Temp.:
50 °C
Hydrolysis rate constant:
< 10
Remarks on result:
hydrolytically stable based on preliminary test
Remarks:
<10% decomposition at 5 days.
pH:
7
Temp.:
50 °C
Remarks on result:
hydrolytically stable based on preliminary test
Remarks:
<10% decomposition at 5 days.
pH:
9
Temp.:
50 °C
Remarks on result:
hydrolytically stable based on preliminary test
Remarks:
<10% decomposition at 5 days.

In the test at pH 4, 7 and 9, less than 10 % decomposition was observed after 5 days at 50 °C. The test substance is therefore considered hydrolytically stable.

Validity criteria fulfilled:
not specified
Conclusions:
The test material was considered to be hydrolytically stable at pH 5, 7, & 9 under the conditions of the preliminary test.

Description of key information

The study provided was conducted to recognised testing guidelines and with GLP certification.

Key value for chemical safety assessment

Additional information

The potential of the test substance to hydrolyse was investigated in a GLP study according to EEC directive 79/831. At pH 4, 7 and 9, less than 10 % decomposition was observed after 5 days at 50 °C (Ciba-Geigy, 1983a).