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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

Currently viewing:

Administrative data

Endpoint:
additional toxicological information
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
Not reported
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Study was not assessed for reliability; provided for information purposes only.

Data source

Reference
Reference Type:
publication
Title:
Acute and Short-term Toxicity Studies on Di-n-butyltin Dichloride in Rats
Author:
Gaunt et al
Year:
1968
Bibliographic source:
Fd Cosmet. Toxicol. Vol. 6, pp. 599-608. Pergamon Press 1968. Printed in Great Britain

Materials and methods

Type of study / information:
Bile duct and hepatic effects.
Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Subchronic (90 d) toxicity study on rats with a focus on duodenal and pancreas effects
GLP compliance:
no
Remarks:
pre-dates GLP

Test material

Constituent 1
Reference substance name:
Dibutyltin dichloride
EC Number:
211-670-0
EC Name:
Dibutyltin dichloride
Cas Number:
683-18-1
IUPAC Name:
dibutyltin dichloride
Constituent 2
Reference substance name:
dibutyltin chloride
IUPAC Name:
dibutyltin chloride

Results and discussion

Any other information on results incl. tables

The present study failed to show any damage to the bile duct even in rats fed at 80 ppm of the diet.

Applicant's summary and conclusion

Conclusions:
The present study failed to show any damage to the bile duct even in rats fed at 80 ppm of the diet.
Executive summary:

The present study failed to show any damage to the bile duct even in rats fed at 80 ppm of the diet.