Registration Dossier
Registration Dossier
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EC number: 404-600-7 | CAS number: 129009-88-7 EVERZOL ORANGE GR; ORANGE HF-SNK; REAKTIV ORANGE FD 19969 FW
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 August 2000 to 31 August 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- no
- GLP compliance:
- yes
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- >= 1.47 - <= 2.99
- Temp.:
- 22 °C
- Remarks on result:
- other: at 276.5 nm
- No.:
- #1
- pKa:
- >= 1.26 - <= 2.89
- Temp.:
- 22 °C
- Remarks on result:
- other: at 405 nm
- No.:
- #2
- pKa:
- >= 1.31 - <= 2.57
- Temp.:
- 22 °C
- Remarks on result:
- other: at 276.5 nm
- No.:
- #2
- pKa:
- >= 1.11 - <= 2.23
- Temp.:
- 22 °C
- Remarks on result:
- other: at 405 nm
- Conclusions:
- The dissociation constant of the test substance at room temperature (22 deg C) was determined within this study as pKa between 1.47 and 2.15 for the acid range, using the five mean values of three experiments.
The pKa value for the alkaline range was not determined because it was not recognised as a real one. The investigations for the hydrolysis show the decomposition of the test substance in alkaline solutions. The abiotic hydrolysis data of all reactive-dyes, determined at the testing facility resulted in a half-life period at pH9 and 25 deg C of less than one day. - Executive summary:
The determination of the pKa in the acid and alkaline range was carried out according to OECD guideline 112.
The dissociation constant of the test substance at room temperature (22 deg C) was determined within this study as pKa between 1.47 and 2.15 for the acid range, using the five mean values of three experiments.
The pKa value for the alkaline range was determined within this study as pKa between 4.91 and 11.77 based on five/six mean values obtained from three experiments.
The pKa value for the alkaline range was not determined because it was not recognised as a real one. The investigations for the hydrolysis show the decomposition of the test substance in alkaline solutions. The abiotic hydrolysis data of all reactive-dyes, determined at the testing facility resulted in a half-life period at pH9 and 25 deg C of less than one day.
Reference
The determination of the pKa in the acid and alkaline range was carried out according to OECD guideline 112.
The dissociation constant of the test substance at room temperature (22 deg C) was determined within this study as pKa between 1.47 and 2.15 for tbhe acid range, using the five mean values of three experiments.
The pKa value for the alkaline range was determined within this study as pKa between 4.91 and 11.77 based on five/six mean values obtained from three experiments.
The pKa value for the alkaline range was not determined because it was not recognised as a real one. The investigations for the hydrolysis show the decomposition of the test substance in alkaline solutions. The abiotic hydrolysis data of all reactive-dyes, determined at the testing facility resulted in a half-life period at pH9 and 25 deg C of less than one day.
Description of key information
The dissociation constant of the test substance at room temperature (22° C) was determined within this study as pKa between 1.47 and 2.15 for the acid range, using the five mean values of three experiments.
The pKa value for the alkaline range was not determined because it was not recognised as a real one. The investigations for the hydrolysis show the decomposition of the test substance in alkaline solutions. The abiotic hydrolysis data of all reactive-dyes, determined at the testing facility resulted in a half-life period at pH9 and 25° C of less than one day.
Key value for chemical safety assessment
Additional information
The determination of the pKa in the acid and alkaline range was carried out according to OECD guideline 112.
The dissociation constant of the test substance at room temperature (22° C) was determined within this study as pKa between 1.47 and 2.15 for the acid range, using the five mean values of three experiments.
The pKa value for the alkaline range was not determined because it was not recognised as a real one. The investigations for the hydrolysis show the decomposition of the test substance in alkaline solutions. The abiotic hydrolysis data of all reactive-dyes, determined at the testing facility resulted in a half-life period at pH9 and 25° C of less than one day. (Mühlberger B, 2000).
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