Registration Dossier
Registration Dossier
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EC number: 209-128-3 | CAS number: 556-52-5
Endpoint summary
Administrative data
Description of key information
Additional information
A study by Klein, 1978, was provided as the key study (Klimisch 2) to evaluate the short term toxicity of 2,3 -epoxypropanol (Glycid) to fish. The 48 -hour LC0 was found to be 140 mg/L for Leuciscus idus melanotus.
Two QSAR reports were also supplied. An ECOSAR model and the OECD (Q)SAR Toolbox were run. ECOSAR estimated the 96 -hour LC50 to be 333.48 mg/L based on the mono epoxide class. OECD (Q)SAR Toolbox estimated the 96 -hour LC50 value to be 50.1 mg/L based on the mono epoxide class.
Two QSAR reports were provided to address short-term toxicity to aquatic invertebrates. Both the ECOSAR and the OECD (Q)SAR model were run. ECOSAR estimated the 48 -hour EC50 to be 2176.8 mg/L based on the mono epoxides class. OECD (Q)SAR Toolbox estimated the 96 -hour EC50 to be 334 mg/L.
A study by Bollman, 1989, was provided to address the toxicity of 2,3 -epoxypropanol (glycid) to algae. The 96 -hour EC50 was found to be 144.7 mg/L for Selenastrum capricornutum.
A study by Klein, 1978, was provided as the key study to address toxicity of 2,3 -epoxypropanol to microorganisms. The 3 hour LC0 was found to be 5600 mg/L.
According to Directive 67/548/EEC and Regulation (EC) No. 1272/2008, the substance does not warrant classification based on the results of the above studies and as the substance is readily biodegradable.
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