Registration Dossier

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 201 (Alga, Growth Inhibition Test)
Deviations:
yes
Remarks:
deviations were considered as uncritical
Principles of method if other than guideline:
Deviations:
1) The temperature in the main study was higher than stated in the guideline. Because the algae showed a normal growth, this deviation was stated as uncritical.
2) The temperature in the reference study was higher than stated in the guideline. Because the algae showed a normal growth, this deviation was stated as uncritical.
GLP compliance:
yes (incl. certificate)
Analytical monitoring:
yes
Vehicle:
no
Test organisms (species):
Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
72 h
Reference substance (positive control):
yes
Remarks:
potassium dichromate
Duration:
72 h
Dose descriptor:
NOEC
Effect conc.:
6.5 mg/L
Nominal / measured:
meas. (arithm. mean)
Conc. based on:
test mat.
Basis for effect:
growth rate
Duration:
72 h
Dose descriptor:
LOEC
Effect conc.:
17.1 mg/L
Nominal / measured:
meas. (arithm. mean)
Conc. based on:
test mat.
Basis for effect:
growth rate
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
> 33 mg/L
Nominal / measured:
meas. (arithm. mean)
Conc. based on:
test mat.
Basis for effect:
growth rate
Validity criteria fulfilled:
yes
Conclusions:
EC50 (72 h) > 33 mg/L
NOEC (72 h) = 6.5 mg/L
Executive summary:

EC50 > 33 mg/L, no acute aquatic hazard, category 1 classification

Description of key information

NOEC(72 h) = 6.5 mg/L		
LOEC(72 h) = 17.1 mg/L
EC50(72 h) > 33 mg/L

Key value for chemical safety assessment

EC50 for freshwater algae:
33 mg/L
EC10 or NOEC for freshwater algae:
6.5 mg/L

Additional information