Registration Dossier
Registration Dossier
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EC number: 306-085-3 | CAS number: 95912-89-3
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects up to the limit of water solubility (< 1 mg/L) for activated sludge (OECD 301B, toxicity control)
Key value for chemical safety assessment
Additional information
There are no studies on toxicity to microorganisms available for Fatty acids, C8-10, mixed esters with adipic acid and trimethylolpropane (CAS No. 95912-89-3). However, in accordance with Annex VIII, column 2,9.1.4 of Regulation (EC) No. 1907/2006, activated sludge respiration inhibition testing is not required since the substance is highly insoluble in water.
Additionally, a substance can be assumed to be not inhibitory to aquatic microorganisms, if in the toxicity control of a ready biodegradation test, more than 35% degradation based on TOC removal occurred within 14 days (OECD guidance 301). For the category member Mixed esters of fatty acid C16 and C16-C18-unsatd. with adipic acid and pentaerythritol a biodegradation test according to OECD guideline 301B is available (Bizzaro and Limiroli, 2012), which includes a toxicity control containing of about 19.94 mg/L of test substance. The toxicity control attained 79% degradation after 14 days of incubation. Hence, the substance was not toxic to aquatic microorganisms in the toxicity control and the highest test concentration of 19.94 mg/L can be determined as NOEC.
This assumption is confirmed by a supporting study, which is not sufficient to cover this endpoint as only a short abstract is available (Laboratorium ECCA NV, 1992). In a growth inhibition test with Pseudomonas putida performed similar to ISO guideline 10712, no inhibition was observed up to a 10% test substance concentration in medium during a test period of 96 h.
All these results combined with the ready biodegradability (78.1 – 84.7% biodegradation after 28 d) of Fatty acids, C8-10, mixed esters with adipic acid and trimethylolpropane imply low toxicity to activated sludge microorganisms.
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