Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
09 February 2010 – 19 April 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: This study has been performed according to OECD and EC guidelines and according to GLP principles.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report Date:
2010

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
other: estimation
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Blown rapeseed oil
- Substance type: Yellow to brown viscous liquid
- Physical state: liquid
- Analytical purity: treated as 100% pure
- Expiration date of the lot/batch: 16 December 2010
- Stability under test conditions: stable
- Storage condition of test material: At room temperature in the dark

Results and discussion

Partition coefficientopen allclose all
Type:
Pow
Partition coefficient:
> 1 000 000
Temp.:
20 °C
pH:
6.9
Type:
log Pow
Partition coefficient:
> 6
Temp.:
20 °C
pH:
6.9
Details on results:
n-Octanol solubility
After stirring for 50 hours, the test solution with a nominal concentration of 1065 g/L was a clear solution without undissolved test substance. Based on this, it was concluded that the solubility of Blown rapeseed oil in n-octabol at 19.9 x 0.8°C is > 1000 g/L.

Water solubility
Information on the water solubility of the test substance is given in section 4.8. The water solubility was < 1 x 10^-3 g/L.

Applicant's summary and conclusion

Conclusions:
The estimation method was used for the determination of the partition coefficient of Blown rapeseed oil. The Pow and log Pow value of the test substance at 20°C was calculated from the n-octanol solubility and the water solubility to be > 1 x 10^6 and > 6, respectively.