Registration Dossier
Registration Dossier
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EC number: 252-200-4 | CAS number: 34762-90-8
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 0.13 mg/L
- EC10 or NOEC for marine water algae:
- 0.049 mg/L
Additional information
A study was conducted to determine the toxicity of the test substance, trichloro(N,N-dimethyloctylamine)boron, to the green algae Pseudokirchneriella subcapitata. according to OECD Guideline 201 and EU Method C3, in compliance with GLP. Following a preliminary range-finding test, the algae were exposed to solutions of the test substance at nominal concentrations of 6.25, 12.5, 25, 50 and 100% v/v saturated solution (three replicate flasks per concentration) for 72 hours, under constant illumination and shaking at a temperature of 24 ± 1 °C. Analysis of the test preparations at 0 hours showed measured test concentrations to range from 0.027 to 0.95 mg/L. A slight decline in measured test concentrations was observed at 72 hours in the range of 0.018 to 0.78 mg/L (68% to 83% of the 0 hour measured test concentrations) and hence it was considered appropriate to calculate the results based on the geometric mean measured test concentration only in order to give a “worst case” analysis of the data. Under the study conditions, the nominal 72 h EC50 were found to be 0.13 and 0.0068 mg/L based on growth rate and yield respectively and 72 NOAEC were found to be 0.022 mg/L based on growth rate and yield (Harlan, 2014).
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