Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Details on test material:
- - Name of test material (as cited in study report): Thiazol Blau
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
NA - Radiolabelling:
- no
Results and discussion
- Details on results:
- The test on the abiotic degradation was not performed.
Reason:
The determination of the hydrolysis rate as a function of the pH-value according to the guideline was not possible, because the described method is only suitable for soluble substances. In order to analyse the hydrolysis rate the solubility of the test item in water has to be much higher than the detection limit of the analytical method (HPLC).
The water solubility of the test item was determined to be lower than 27 µg/l (refer to report no. 20090163.02) which corresponds to the detection limit of the analytical method (HPLC). Therefore the study of the hydrolysis does not need to be conducted.
Applicant's summary and conclusion
- Conclusions:
- The solubility of the test item in water is extremely low. The water solubility of the test item was determined to be lower than 27 µg/l (refer report no. 20090163.02). Therefore, an experimental determination of the hydrolysis was not possible, as the described method (OECD guideline 111 and European Commission Regulation (EC) No. 440/2008, C.7.) is only suitable for water soluble substances.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
