Registration Dossier
Registration Dossier
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EC number: 225-967-8 | CAS number: 5187-23-5
Toxicity to reproduction
Administrative data
- Endpoint:
- extended one-generation reproductive toxicity - basic test design (Cohorts 1A, and 1B without extension)
- Remarks:
- Including Cohort 1C
- Type of information:
- experimental study planned
- Justification for type of information:
- Testing Proposal for OECD 443 study - EOGRT:
A testing proposal is suggested on this endpoint as no available studies (neither GLP or non-GLP) nor historical human data are available to cover the information requirements for this tonnage level. Any potential grouping and read across has been evaluated. The use of (Q)SAR as well as in vitro methods are limited for this type of endpoint. There therefore is no possibility to fill the data gap by any other means than performing the proposed test.
Data source
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 443 (Extended One-Generation Reproductive Toxicity Study)
- Justification for study design:
- As in accordance with the data requirements in REACH annex X.
Test material
- Reference substance name:
- 5-ethyl-1,3-dioxane-5-methanol
- EC Number:
- 225-967-8
- EC Name:
- 5-ethyl-1,3-dioxane-5-methanol
- Cas Number:
- 5187-23-5
- Molecular formula:
- C7H14O3
- IUPAC Name:
- (5-ethyl-1,3-dioxan-5-yl)methanol
- Test material form:
- liquid
- Details on test material:
- 5-ethyl-1,3-dioxan-5-yl)methanol / 5187-23-5 / 225-967-8
Constituent 1
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
