Registration Dossier
Registration Dossier
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EC number: 201-497-9 | CAS number: 83-73-8
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- other: Authoritative data base
- Title:
- HSDB Number: 3224
- Author:
- HSDB database
- Year:
- 2 011
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank); US national Library of Medicine reviewed by SRC,Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975. ,p.1073
- Reference Type:
- other: Authoritative data base
- Title:
- GCID: 477779
- Author:
- ACToR database
- Year:
- 2 011
- Bibliographic source:
- ACToR (Aggregated Computational Toxicology Resource),Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 1073
Materials and methods
- Objective of study:
- absorption
- excretion
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from HSDB and ACToR database.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diiodohydroxyquinoline
- EC Number:
- 201-497-9
- EC Name:
- Diiodohydroxyquinoline
- Cas Number:
- 83-73-8
- Molecular formula:
- C9H5I2NO
- IUPAC Name:
- 5,7-diiodoquinolin-8-ol
- Details on test material:
- - Name of test material: diiodohydroxyquinoline
- Molecular formula: C9H5I2NO
- Molecular weight: 396.95
- Substance type: organic
- Physical state: solid
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- other: no data
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Variable but significant portion of ingested dose was absorbed, diiodohydroxyquin was least well absorbed, only 1/3 as much as iodochlorhydroxyquin
- Details on excretion:
- Bulk of these drugs was passed in feces.
Metabolite characterisation studies
- Metabolites identified:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
After an oral administration of diiodohydroxyquinoline it was found that diiodohydroxyquin was least well absorbed, only 1/3 as much as iodochlorhydroxyquin, and bulk of it was passed in feaces. - Executive summary:
After an oral administration of diiodohydroxyquinoline it was found that diiodohydroxyquin was least well absorbed, only 1/3 as much as iodochlorhydroxyquin, and bulk of it was passed in feaces.
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