Registration Dossier
Registration Dossier
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EC number: 202-257-6 | CAS number: 93-55-0
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
The substance is expected to have a low potential for adsorption.
Key value for chemical safety assessment
Additional information
There are no experimental available data on the adsorption/desorption potential of propiophenone, however this property can be screened, on the basis of the partition coefficient octanol-water.
As mentioned in the specific endpoint (Iuclid section 4.7) the log Pow of propiophenone has been investigated uding fast-gradient HPLC method, which was developed to estimate the lipophilicity of substances. Propiophenone was used as a reference compound and its retention time was used to estimated the logPow of other substances. An excellent correlation was found between the results of the experimental determined and the literature log P values. The log Pow of the substance resulted to be 2.71 (Zheng.and West, 2009), thus, based on the physicochemical properties, the substance can be expected to have a low potential for adsorption.
The adsorption potential has also been estimated using KOCWIN v2.00, for completeness sake. The results confirm the expectation of a low potential for adsorption.
Soil Adsorption Coefficient Koc has been estimated as 98.9 l/kg (log Koc: 1.995), based on the MCI method; the calculation based on the kow method identified a Koc of 416.6 l/kg (log Koc: 2.620).
The estimation has been performed entering the experimental determined logPow of 2.71.
Furthermore, information on the structural analoguous acetophenone are available from literature source (Southworth and Keller, 1986). The sorption of acetophenone by three soils having different organic-carbon (OC) contents was determined. The substance showed sorption coefficient values (Koc) of 185 in soil with OC cotent of 0.11 %, 270 in soil with OC content of 0.05 % and 105 in soil with OC content of 1.2 %, confirming the behaviuor ecpected for propiophenone.
REFERENCE
KOCWIN v.2.00 is an application contained in the EpiSuite 4.1, the suite of physical/chemical property and environmental fate estimation programs developed by the EPA’s Office of Pollution Prevention Toxics and Syracuse Research Corporation (SRC).
Southworth and Keller, 1986. Hydrophobic sorption of polar organics by low organic carbon soils. Water, Air, and Soil Pollution 28 (1986) 239-248.
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