Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 480-070-0 | CAS number: 85-27-8
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- other: Review and expert statement
- Adequacy of study:
- supporting study
- Reliability:
- other: not applicable
Data source
Referenceopen allclose all
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2011
- Reference Type:
- publication
- Title:
- Inhibition of Melanin formation by chemical agents.
- Author:
- Denton, C. R.; et al.
- Year:
- 1 952
- Bibliographic source:
- Journal of investigative dermatology, 18: 119-135
- Reference Type:
- publication
- Title:
- Mechanism of depigmentation by hydrochinone.
- Author:
- Jimbow, K.; et al.
- Year:
- 1 974
- Bibliographic source:
- Journal of Investigative dermatology, 62: 436-449
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Evaluation of the dermal absorption potential of SymWhite 377.
- GLP compliance:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 480-070-0
- EC Name:
- -
- Cas Number:
- 85-27-8
- Molecular formula:
- C14H14O2
- IUPAC Name:
- 4-(1-phenylethyl)benzene-1,3-diol
- Details on test material:
- Test item: SymWhite 377
Physical state: Solid, white to beige powder
Storage conditions: Ambient temperature, dark, dry and in original container
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Due to the high water solubility (>3 g/L) and a logPow of 2.11, quantitatively relevant dermal absorption can not be completely ruled out based on theoretical considerations only. However, the lack of toxicity in the acute dermal toxicity study up to a concentration of 2000 mg/kg bw in comparison to the acute oral toxicity (LD50 300-2000 mg/kg bw) may be seen as an indication that this is not a preferential route of entry into the body.
SymWhite 377 is intended to be used at a low application rate as a topical skin lightening agent/antioxidant. Therefore, and in analogy to hydroquinone it may be hypothesised that after uptake into the skin layer, SymWhite 377 inhibits the enzymatic oxidation of tyrosine to dopa, which is the first reaction step in melanogenesis . Furthermore, there is indication that the second step in melanogenesis, the oxidation of dopa to melanin by tyrosinase, is also affected by hydroquinone .
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
