Registration Dossier
Registration Dossier
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EC number: 209-943-4 | CAS number: 598-63-0
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test method and test sytem are described in details. Acceptable, well-documented publication which meets basic scientific principles .
Data source
Reference
- Reference Type:
- publication
- Title:
- Reduction of the mutagenicity of lead chromate-based pigments by encapsulation with silica
- Author:
- Thomas H. Connor and Stanley M. Pier
- Year:
- 1 990
- Bibliographic source:
- Mutation Research 245, 129-133
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 13 lead chromate-based pigments were assayed for mutagenicity and toxicity using salmonella typhimurium TA100.
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Lead carbonate
- EC Number:
- 209-943-4
- EC Name:
- Lead carbonate
- Cas Number:
- 598-63-0
- Molecular formula:
- CH2O3.Pb
- IUPAC Name:
- λ²-lead(2+) carbonate
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 100
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9
- Test concentrations with justification for top dose:
- 500, 100 & 50µg per plate
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- not specified
- Positive controls:
- yes
- Positive control substance:
- other: sodium azide & cyclophosphamide
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
In the conditions of the study, lead carbonate was found non toxic nor mutagenic.
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