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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: The study summarizes a lot of experimental resuts but does not give any details on testing methodology Documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Studies on the toxicity of various lead compounds given intravenously
Author:
Fritz Bischoff, L.C. maxwell, Richard D. Evans, and Franklin R. Nuzum
Year:
1928
Bibliographic source:
Journal of Pharmacology and Experimental Therapeutics 34:85-109,192

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
A comparative study of the effects upon the rabbit of a series of different lead compounds was made, with the idea that such information may assist in elucidating the ultimate problem. The effect upon the hemoglobin, the lethal dose, damage to the liver and kidney, and the effect upon the chorionic epithelium and upon the progeny have been considered.
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Lead carbonate
EC Number:
209-943-4
EC Name:
Lead carbonate
Cas Number:
598-63-0
Molecular formula:
CH2O3.Pb
IUPAC Name:
lead carbonate

Test animals

Species:
rabbit
Strain:
not specified
Sex:
female

Administration / exposure

Route of administration:
intravenous
Vehicle:
not specified
Doses:
8 to 10 mg/Kg
No. of animals per sex per dose:
3

Results and discussion

Mortality:
In the one pregnant rabbit studied, six out of the nine young born, died after birth.
Other findings:
The destruction of the red cells is not nearly so marked as for an equivalent amount of lead hydroxide. The fall in hemoglobin begins rather sooner than with the oxy carbonate.
It is necessary to consider lead carbonate as one of the reaction products of colloidal metallic lead or ionic lead with the salts of the blood. The fact that it is more toxic than the phosphate is of interest.

Applicant's summary and conclusion

Conclusions:
The toxic effects of lead given intravenously depend entirely upon the lead compound given. Lead carbonate is included in the second most toxic group. These compounds are very insoluble and probably are removed from the blood stream before they have had a chance to react with the constituents of the blood.

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