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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Study period:
9 weeks
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well-documented publication which meets basic scientific principles

Data source

Reference
Reference Type:
publication
Title:
Effets de l'intoxication par le plomb sur les propriétés des mitochondries de cerveau de jeune rat
Author:
Paul Dumas, Daniel Gueldry, Annie Loireau, Philoppe Chomard, Anne-Marie Buthieau and Nicole Autissier
Year:
1985
Bibliographic source:
C. R. Biol. 179, 175-183

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Young Wistar rats of 14d were fed with powdered chow containing lead carbonate during some weeks.
GLP compliance:
not specified
Test type:
fixed dose procedure
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Lead carbonate
EC Number:
209-943-4
EC Name:
Lead carbonate
Cas Number:
598-63-0
Molecular formula:
CH2O3.Pb
IUPAC Name:
lead carbonate

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified

Administration / exposure

Route of administration:
oral: feed
Vehicle:
unchanged (no vehicle)
Doses:
1,2 and 4%
No. of animals per sex per dose:
1% : 10mice + 7 controls
2%
4%
Control animals:
yes

Results and discussion

Any other information on results incl. tables

Growth is clearly slowed at 1% of lead carbonate in food.

During 9 weeks, weight of test mice were lower than controls as the concentration of lead carbonate increased. Moreover, cerebral mitochondrial cells accumulated lead consecutively to the lead carbonate concentration in food.

In vitro trials showed that lead accumulated in mitochondrial cells induced alteration, whereas in vivo results were ambiguous : lead is accumulated as an insoluble less toxic form thanks to a complexation with inorganic phosphate.

Applicant's summary and conclusion

Interpretation of results:
sligthly toxic
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
In the conditions of the study, lead carbonate was found to be slightly toxic.

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