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Diss Factsheets

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well-documented publication which meets basic scientific principles

Data source

Reference
Reference Type:
publication
Title:
Percutaneous absorption of inorganic lead compounds
Author:
Stauber JL, Florence TM, Gulson BL, Dale LS.
Year:
1994
Bibliographic source:
The Science of the Total Environment 145(1-2):55-70

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The aim of this study was to monitor the uptake and the transport of skin-absorbed inorganic lead compounds in sweat, urine, and blood of human volunteers using a stable lead isotope enriched in 204Pb.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Lead carbonate
EC Number:
209-943-4
EC Name:
Lead carbonate
Cas Number:
598-63-0
Molecular formula:
CH2O3.Pb
IUPAC Name:
λ²-lead(2+) carbonate
Constituent 2
Reference substance name:
PbCO3
IUPAC Name:
PbCO3
Radiolabelling:
yes

Test animals

Species:
human
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Control animals:
no

Results and discussion

Any other information on results incl. tables

Lead carbonate as showed in preleminary experiments was not absorbed through the skin.

Applicant's summary and conclusion

Conclusions:
In the conditions of the studies, lead carbonate was not found toxic through dermal absorption.