Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
biotransformation and kinetics
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well-documented publication which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Bioaccessibility measurement of soil samples from 4 locations at a site contaminated with mining waste and located in a high carbonate soil in the south of France. The test consists a 3-step extraction procedure and simulates the chemical processes occuring in the mouth, stomach and intestine compartments using synthetic digestive solutions.
GLP compliance:
not specified
Type of medium:
terrestrial

Test material

Constituent 1
Reference substance name:
Cerussite
IUPAC Name:
Cerussite

Results and discussion

Transformation products:
not specified

Any other information on results incl. tables

For all soil samples Pb bioavailability was significantly higher in the saliva-gastric phase compared to the intestinal phase. Higher bioavailability in gastric phase is due to the lower pH which facilitated lead dissolution.

Sequential extraction was used and allowed to detect that PbCO3 was not occuring anymore in the residual fractions.

Applicant's summary and conclusion

Conclusions:
This study confirms that Pb carbonate forms and particularly Cerussite are highly bioaccessible.

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