Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

No toxicokinetic or metabolism studies are available for ditolylether. Due to the close structural similarity with diphenylether, diphenylether is used as a surrogate. This is in accordance with the BUA report no 193 for ditolylether (GDCh-Advisory Committee on Existing Chemicals of Environmental Relevance ( BUA).

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

No toxicokinetic or metabolism studies are available for ditolylether. Due to the close structural similarity with diphenylether, diphenylether is used as a surrogate. This is in accordance with the BUA report no 193 for ditolylether (GDCh-Advisory Committee on Existing Chemicals of Environmental Relevance ( BUA).

In a toxicokinetic study, blood levels of radioactive labelled [14C]diphenyl ether in rats after oral application of the substance were measured. Additional tissue distribution of [14C]diphenyl ether in rats after ip application was examined. After i.p. administration of [14C]diphenyl ether (5 mg/kg) to rats, radioactivity was detected in all organs and tissues. After intragastric administration of [14C]diphenyl ether (10 mg/kg) to rats, unchanged diphenyl ether in the blood was at max. concentration within 15 hours and decreased linearly with time, with a biological half-life of about 1.5 hours. More than 90% of the intragastrically administered dose was excreted in urine and faeces within 3 days; > 80% dose in the urine.