Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: 4e: Documentation insufficient for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980

Materials and methods

Principles of method if other than guideline:
other
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-methylthiosemicarbazide
EC Number:
229-563-2
EC Name:
4-methylthiosemicarbazide
Cas Number:
6610-29-3
Molecular formula:
C2H7N3S
IUPAC Name:
1-amino-3-methylthiourea
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: ocular
Vehicle:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
15 - 30 mg/kg bw

Applicant's summary and conclusion

Conclusions:
MTSC was quite toxic when placed in the eye, the rabbit ocular LD50 was 15-30 mg/kg.