Registration Dossier

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: 4e: Documentation insufficient for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Rats were exposed one hour to an atmospheric concentration of 0.4 mg compound per liter air.
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-methylthiosemicarbazide
EC Number:
229-563-2
EC Name:
4-methylthiosemicarbazide
Cas Number:
6610-29-3
Molecular formula:
C2H7N3S
IUPAC Name:
1-amino-3-methylthiourea
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Vehicle:
other:
Duration of exposure:
1 h
Concentrations:
0.4 mg/l
No. of animals per sex per dose:
no data
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC0
Effect level:
> 0.4 mg/L air
Exp. duration:
1 h
Mortality:
No deaths were reported
Clinical signs:
other: No toxic effects were noted.

Applicant's summary and conclusion

Conclusions:
Signs of toxicity were not observed when rats were exposed one hour to an atmospheric concentration of 0.4 mg/ml of MTSC. The crystalline nature of MTSC probably reduces inhalational hazards.