Dimethyl 5-[[1-[[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)amino]carbonyl]-2-oxopropyl]azoterephthalate

Nanomaterial dustiness

Administrative data

Endpoint:

nanomaterial dustiness

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods

Remarks:

according to DIN EN 17199-3

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Report date:

2020

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: DIN EN 17199-3

Version / remarks:

measurement of dustiness of bulk materials that contain or release respirable NOAA or other respirable particles - Part 3: Continuous drop method

Deviations:

yes

Remarks:

test conditions (temperature, humidity) due to laboratory environment; 1 meaurement performed

GLP compliance:

no

Type of method:

continuous drop

Sampling:

The test material was used without further treatment (e.g. drying). 37.3 g (160.0 cm3) test material are used for the measurement, dosing rate: 3.7 g/min

Test material

Test material information

Constituent 1

Reference substance name:

Dimethyl 5-[[1-[[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)amino]carbonyl]-2-oxopropyl]azoterephthalate

EC Number:

249-955-7

EC Name:

Dimethyl 5-[[1-[[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)amino]carbonyl]-2-oxopropyl]azoterephthalate

Cas Number:

29920-31-8

Molecular formula:

C21H19N5O7

IUPAC Name:

dimethyl 5-({2-oxo-1-[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)carbamoyl]propyl}diazenyl)isophthalate

Test material form:

solid: nanoform

Results and discussion

Dustiness index

Dustiness index 1

Key result

Mean:

636 777.46 other: 1/mg

Remarks on result:

other: dustiness index as number of airborne particles per mg in the nanoscale (10 nm - 100 nm)

Dustiness index 2

Mean:

44 814.72 other: N/cm3

Remarks on result:

other: number of airborne nanoparticles per cm3

Any other information on results incl. tables

meaurment duration: 10 min, temperature: 15°C, rel. air humidity 55 %

The cleaned, almost particle-free air had a total particle count of 177 particles/cm³ in the range of 10 nm - 417 nm, the nanoscale fraction (10 - 100 nm) contained 127 particles/cm³.

table 1: summary SMPS (sanning mobility particle sizer)

Range [nm]	Mean [nm]	Concentration [N/cm^3]	ICD[1/mg]	ECD[1/mg x s]
10 - 100	66.45	44814.72	636777.46	1061.30
100 - 417	141.76	46352.90	658633.74	1097.72
10 - 417	104.74	91167.62	1295411.20	2159.02

I_CD: dustiness index as number of airborne particles per mg

E_CD: emission rate as number of particles per mg per second

mean: average particle diameter in nm

N: number of airborne particles

table 2: summary OPS (optical particle sizer)

Range [µm]	Mean [µm]	Concentration [N/cm^3]	ICD[1/mg]	ECD[1/mg x s]
0.3 - 10	5.18	60.35	857.52	1.43

Applicant's summary and conclusion

Executive summary:

The dusting behaviour of the test material was investigated using DIN EN 17199 -3: 2019 -12 "workplace exposure - measurement of dustiness of bulk materials that contain or release respirable nano objects and their aggregates and agglomerates or other respirable particles- Part 3: Continuous drop method".

The dust released by the falling test material was measured by a scanning mobility particle sizer (SMPS, 10 - 417 nm) and an optical particle sizer (3 - 10 µm). The counterflow was provided by cleaned, almost particle-free air.

The SMPS counted 91167.62 airborne particles per cm³ (44814.72 particles in the nanoscale (10 - 100 m) ) corresponding to a dustiness index of 1295411.20 airborne particles per mg (636777.46 in the nanoscale (10 - 100 nm)) . The mean size of the nanoparticles was 66.45 nm, the mean size of particles in the range 10 - 417 nm was 104.74 nm.

The OPS (0.3 - 10 µm) counted 60.35 particles per cm³ corresponding to a dustiness index of 857.52 particles per mg. The mean size of the particles was 5.18 µm.