Registration Dossier
Registration Dossier
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EC number: 202-150-4 | CAS number: 92-36-4
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study published in Literature. No details on GLP and/or Guideline followed.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Guideline:
- other: no data
- Principles of method if other than guideline:
- See publication for details
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-(6-methylbenzothiazol-2-yl)aniline
- EC Number:
- 202-150-4
- EC Name:
- 4-(6-methylbenzothiazol-2-yl)aniline
- Cas Number:
- 92-36-4
- Molecular formula:
- C14H12N2S
- IUPAC Name:
- 4-(6-methyl-1,3-benzothiazol-2-yl)aniline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 10 days: 5 days followed by 2 rest days and 5 more exposure days.
- Frequency of treatment:
- 6h/d
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.68 mg/l
Basis:
no data
- No. of animals per sex per dose:
- 10
- Control animals:
- yes, sham-exposed
- Details on study design:
- given in publication
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- Changes in Liver weight, changes in spleen weight, Changes in erythrocyte (RBC count)
- Mortality:
- mortality observed, treatment-related
- Description (incidence):
- Changes in Liver weight, changes in spleen weight, Changes in erythrocyte (RBC count)
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- Weight loss
- Haematological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- increased serum enzyme activity, kidney turbular degeneration in one rat
- Urinalysis findings:
- effects observed, treatment-related
- Description (incidence and severity):
- excetion of large volumes of less concentrated urine
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Description (incidence and severity):
- increased liver weight
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Liver changes
Effect levels
open allclose all
- Dose descriptor:
- other: TCLo
- Effect level:
- 680 mg/kg bw/day (actual dose received)
- Sex:
- male
- Dose descriptor:
- conc. level: TCLo
- Effect level:
- 0.68 mg/L air (analytical)
- Sex:
- male
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The study was performed as a 10 days subchronic study. The results justify a classification as STOT RE 2.
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