Registration Dossier

Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
fertility, other
Remarks:
based on test type (migrated information)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
RTECS Number : MA3740000
Author:
RTECS database
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances);HPV199 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Dicarboxylic Acid Category.pdf (http://www.epa.gov/HPV/pubs/summaries/viewsrch.htm) Volume(issue)/page/year: 2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from RTECS
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Glutaric acid
EC Number:
203-817-2
EC Name:
Glutaric acid
Cas Number:
110-94-1
IUPAC Name:
glutaric acid
Details on test material:
- Name of test material : glutaric acid

Test animals

Species:
rat
Strain:
not specified
Sex:
female

Administration / exposure

Route of administration:
oral: unspecified
Type of inhalation exposure (if applicable):
not specified
Vehicle:
not specified
Duration of treatment / exposure:
6-15 day(s) after conception
Doses / concentrations
Remarks:
Doses / Concentrations:
1000 mg/kg
Basis:
no data

Results and discussion

Results: P0 (first parental generation)

Effect levels (P0)

Dose descriptor:
other: TDLo - Lowest published toxic dose
Effect level:
1 000 other: mg/kg
Based on:
test mat.
Sex:
female
Basis for effect level:
other: Reproductive - Maternal Effects - other effects

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Toxicity to reproduction (TDLo - Lowest published toxic dose )was examined in rat at a dose concentration of 1000 mg/kg
Executive summary:

Toxicity to reproduction (TDLo - Lowest published toxic dose )was examined in rat at a dose concentration of 1000 mg/kg