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Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
chronic toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The target chemical 3-oxoglutaric acid and the read across chemical belong to the same category; that of “dicarboxylic acid”. Both the chemicals share physico-chemical properties within an acceptable range as well as environmental fate properties and aquatic toxicity properties thereby qualifying for suitable read-across. In general, the most striking pattern across the two chemicals is their low toxicity profile.

Data source

Reference
Reference Type:
review article or handbook
Title:
RTECS Number : MA3740000
Author:
RTECS database
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances);HPV199 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Dicarboxylic Acid Category.pdf (http://www.epa.gov/HPV/pubs/summaries/viewsrch.htm) Volume(issue)/page/year: 2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from RTECS database
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Glutaric acid
EC Number:
203-817-2
EC Name:
Glutaric acid
Cas Number:
110-94-1
IUPAC Name:
glutaric acid
Details on test material:
- Name of test material : glutaric acid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Duration of treatment / exposure:
90 D
Frequency of treatment:
intermittent
Doses / concentrations
Remarks:
Doses / Concentrations:
135 gm/kg
Basis:
no data

Results and discussion

Effect levels

Dose descriptor:
other: TDLo - Lowest published toxic dose
Effect level:
135 other: gm/kg/90D (intermittent)
Based on:
test mat.
Sex:
not specified
Basis for effect level:
other: Nutritional and Gross Metabolic - weight loss or decreased weight gain

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Repeated dose toxicity (TDLo - Lowest published toxic dose ) via oral route was examined in rat at dose concentration of 135 gm/kg/90D (intermittent). Thus, it can be concluded that glutaric acid shall not exhibit repeated dose toxicity via the oral route below the concentration mentioned in the end point.
Executive summary:

Repeated dose toxicity (TDLo - Lowest published toxic dose ) via oral route was examined in rat at dose concentration of 135 gm/kg/90D (intermittent). Thus, it can be conlcuded that glutaric acid shall not exhibit repeated dose toxicity via the oral route below the concentration mentioned in the end point.