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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
chronic toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The target chemical 3-oxoglutaric acid and the read across chemical belong to the same category; that of “dicarboxylic acid”. Both the chemicals share physico-chemical properties within an acceptable range as well as environmental fate properties and aquatic toxicity properties thereby qualifying for suitable read-across. In general, the most striking pattern across the two chemicals is their low toxicity profile.

Data source

Reference
Reference Type:
review article or handbook
Title:
RTECS Number : MA3740000
Author:
RTECS database
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances);HPV199 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Dicarboxylic Acid Category.pdf (http://www.epa.gov/HPV/pubs/summaries/viewsrch.htm) Volume(issue)/page/year: 2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from RTECS database
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Glutaric acid
EC Number:
203-817-2
EC Name:
Glutaric acid
Cas Number:
110-94-1
IUPAC Name:
glutaric acid
Details on test material:
- Name of test material : glutaric acid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Duration of treatment / exposure:
90 D
Frequency of treatment:
intermittent
Doses / concentrations
Remarks:
Doses / Concentrations:
135 gm/kg
Basis:
no data

Results and discussion

Effect levels

Dose descriptor:
other: TDLo - Lowest published toxic dose
Effect level:
135 other: gm/kg/90D (intermittent)
Based on:
test mat.
Sex:
not specified
Basis for effect level:
other: Nutritional and Gross Metabolic - weight loss or decreased weight gain

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
Repeated dose toxicity (TDLo - Lowest published toxic dose ) via oral route was examined in rat at dose concentration of 135 gm/kg/90D (intermittent). Thus, it can be concluded that glutaric acid shall not exhibit repeated dose toxicity via the oral route below the concentration mentioned in the end point.
Executive summary:

Repeated dose toxicity (TDLo - Lowest published toxic dose ) via oral route was examined in rat at dose concentration of 135 gm/kg/90D (intermittent). Thus, it can be conlcuded that glutaric acid shall not exhibit repeated dose toxicity via the oral route below the concentration mentioned in the end point.