Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The target chemical 3-oxoglutaric acid and the read across chemical belong to the same category; that of “dicarboxylic acid”. Both the chemicals share physico-chemical properties within an acceptable range as well as environmental fate properties and aquatic toxicity properties thereby qualifying for suitable read-across. In general, the most striking pattern across the two chemicals is their low toxicity profile.

Data source

Reference
Reference Type:
review article or handbook
Title:
RTECS Number : MA3740000
Author:
RTECS database
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances);HPV199 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Dicarboxylic Acid Category.pdf (http://www.epa.gov/HPV/pubs/summaries/viewsrch.htm) Volume(issue)/page/year: 2001

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Data is from RTECS database - Standard daize test
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material : glutaric acid

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
not specified
Controls:
not specified

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Remarks on result:
other: Dose data : 100 mg

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Eye irritation of glutaric acid in rabbits was examined at dose concentration of 100 mg based on which it is assumed that glutaric acid shall have slight irritation potential to the eye
Executive summary:

Eye irritation of glutaric acid in rabbits was examined at dose concentration of 100 mg based on which it is assumed that glutaric acid shall have slight irritation potential to the eye