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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation / corrosion
Remarks:
other: details not available
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The target chemical 3-oxoglutaric acid and the read across chemical belong to the same category; that of “dicarboxylic acid”. Both the chemicals share physico-chemical properties within an acceptable range as well as environmental fate properties and aquatic toxicity properties thereby qualifying for suitable read-across. In general, the most striking pattern across the two chemicals is their low toxicity profile.

Data source

Reference
Reference Type:
review article or handbook
Title:
RTECS Number : MA3740000
Author:
RTECS database
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances);HPV199 U.S. Environmental Protection Agency; High Production Volume (HPV) Challenge; Dicarboxylic Acid Category.pdf (http://www.epa.gov/HPV/pubs/summaries/viewsrch.htm) Volume(issue)/page/year: 2001

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from RTECS database
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Glutaric acid
EC Number:
203-817-2
EC Name:
Glutaric acid
Cas Number:
110-94-1
IUPAC Name:
glutaric acid
Details on test material:
- Name of test material : glutaric acid

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Remarks on result:
other: Dose data : 0.5 gm ; Reaction Severity : Mild

Applicant's summary and conclusion

Interpretation of results:
other: Mild irritation
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
Skin irritation of glutaric acid in rabbit was examined at dose concentration of 0.5 gm and showed mild irritation potential.
Executive summary:

Skin irritation of glutaric acid in rabbit was examined at dose concentration of 0.5 gm and showed mild irritation potential.