Registration Dossier
Registration Dossier
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EC number: 231-658-9 | CAS number: 7680-73-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Only two results (with limited reliability) are available for acute oral toxicity:
LD50 (rat): 2260 mg/kg bw
LD50 (mouse): 3400 mg/kg bw
Remark: The corresponding publication is referenced in RTECS and ACToR (secondary literature) with the LD50 results 285 mg/kg (rat) and 286 mg/kg (mouse). These values are identical with the corresponding error limits given in the Russian publication and are therefore considered to be wrong.
In addition results (with limited reliability) are available for other administration routes:
LD50 (subcutanous injection, rat): 280 mg/kg
LD50 (intraperitoneal, mouse): 220 mg/kg
Justification for classification or non-classification
The available value for the acute oral toxicity (rat), LD50=2260 mg/kg bw would not lead to a corresponding classification of the substance, according to the criteria given in Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC, Annex VI, 3.1.2-3.1.3.
The available value for the acute oral toxicity (rat), LD50=2260 mg/kg bw would not lead to a corresponding classification of the substance, according to the criteria in Regulation (EC) No. 1272/2008, Annex I, Part 3, 3.1.2.
However since the available result has only limited reliability, this non-classification is considered as "inconclusive".
The results for the subcutaneous and intraperitoneous routes of administration are considered as not relevant for the purpose of classification according to Directive 67/548/EEC and Regulation (EC) No. 1272/2008.
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