Registration Dossier
Registration Dossier
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EC number: 201-857-5 | CAS number: 88-75-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1970
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Inhalation-Risk-Test was performed in principle as described in OECD Guideline 403. It demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at the temperature chosen for vapor generation (20°C).
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-nitrophenol
- EC Number:
- 201-857-5
- EC Name:
- 2-nitrophenol
- Cas Number:
- 88-75-5
- Molecular formula:
- C6H5NO3
- IUPAC Name:
- 2-nitrophenol
- Details on test material:
- - Name of test material (as cited in study report): o-nitrophenol
- Physical state: solid
no further detail provided
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
Air was blown with 200 L/h through the test substance. Animals were exposed to the dust for 8 hours. - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 8 h
- Concentrations:
- 0.22 mg/L
- No. of animals per sex per dose:
- 12
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations: daily
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- 0.22 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: no mortality was seen
- Mortality:
- no animal died
- Clinical signs:
- other: no abnormalities detected
- Gross pathology:
- no abnormalities detected
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
