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Diss Factsheets
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EC number: 642-902-2 | CAS number: 163802-53-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15/01/2013 - 02/02/2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.1100 (Acute Dermal Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-(trimethoxysilyl)propyl (2E,4E)-hexa-2,4-dienoate
- EC Number:
- 642-902-2
- Cas Number:
- 163802-53-7
- Molecular formula:
- C12H22O5Si
- IUPAC Name:
- 3-(trimethoxysilyl)propyl (2E,4E)-hexa-2,4-dienoate
- Reference substance name:
- 3-(trimethoxysilyl)propyl-(2E,4E)-hexa-2,4-dienoate
- IUPAC Name:
- 3-(trimethoxysilyl)propyl-(2E,4E)-hexa-2,4-dienoate
- Reference substance name:
- 2,4-Hexadienoic acid, 3-(trimethoxysilyl)propyl ester, (2E,4E)-
- IUPAC Name:
- 2,4-Hexadienoic acid, 3-(trimethoxysilyl)propyl ester, (2E,4E)-
- Test material form:
- liquid
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- other: WISTAR rats Crl: WI(Han) (full barrier)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, Germany
- Age at study initiation: 8-9 weeks
- Weight at study initiation: males 237-259 g ; females 166-183 g
- Fasting period before study: none
- Housing: The rats were kept individually in IVC cages, type IP H, polysulphone cages on Altromin saw fibre bedding.
- Diet (e.g. ad libitum): Altromin 1324 maintenance diet for rats and mice
- Water (e.g. ad libitum): tap water, sulphur acidified to a pH value of approx. 2.8
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3
- Humidity (%): 55 +/- 10 %
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorsal area of the trunk
- % coverage: 10
- Type of wrap if used: gauze-dressing and non-irritating tape plus additional dressing
REMOVAL OF TEST SUBSTANCE
- Washing: yes
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg per body weight
- Constant volume or concentration used: yes - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 males and 5 non-pregnant females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were weighed on day 1 (prior to the application), on days 8 and 15. Observations for clinical signs were noted 30 minutes after application, then at 4 hours and then daily. Special attention was paid to changes in the skin and fur, eyes and mucous membranes, circulatory, respiratory, autonomic and central nervous system as well as somatomotor activity and behaviour pattern were examined.
- Necropsy of survivors performed: At the end of the study all the surviving animals were killed by overdosage with pentobabrital injected intraperitoneally. All gross pathological changes were recorded.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were no cases of mortality during the 14-day study period.
- Clinical signs:
- other: There were cases of eschar or scratches from day 5 until day 12 in one male. The same effect was observed in 4 females from day 5 until days 9, 15, 7 and 12.
- Gross pathology:
- No significant gross pathological changes were recorded in the tested animals.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute dermal toxicity study conducted to the OECD 402 and to GLP, the LD50 for 2,4-hexadienoic acid, 3-(trimethoxysilyl)propyl ester was > 2000 mg/kg bw in rats.
- Executive summary:
The acute dermal toxicity following the application of a single dose of the test item was determined. The study was performed as a limit test according to OECD 402 and OPPTS 870.1200.
Five male and five female WISTAR Crl: (WI(Han) rats were selected for testing. The fur was removed from the dorsal area of the trunk using an electric clipper. Care was taken to avoid abrading the skin, and only animals with healthy intact skin were used. At least 10% of the body surface was cleared for the application. Prior to application, a detailed clinical observation was made for all animals.
The neat test item was applied uniformly over an area which was approximately 10% of the total body surface. The test item was held in contact with the skin by a dressing throughout the 24 hour period. The dressing consisted of a gauze-dressing and not-irritating tape and was fixed with an additional dressing in a suitable manner.
Under the conditions of the study, single dermal application of the test item to rats at a dose of 2000 mg/kg body weight was associated with neither mortality nor signs of toxicity but signs of irritation. Therefore, the dermal LD50 was determined to be >2000 mg/kg body weight.
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