Registration Dossier
Registration Dossier
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EC number: 221-641-4 | CAS number: 3173-72-6
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented and scientifically acceptable publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Isocyanate asthma: respiratory symptoms due to 1,5-naphthylene diisocyanate
- Author:
- Harries MG et al.
- Year:
- 1 979
- Bibliographic source:
- Thorax 34: 762-766
Materials and methods
- Type of sensitisation studied:
- respiratory
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- Bronchial provocation testing with MDI, TDI, NDI, histamine and exercise according to the method described by O'Brien et al. (Clinical Allergy 9: 1-6, 1979).
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,5-naphthylene diisocyanate
- EC Number:
- 221-641-4
- EC Name:
- 1,5-naphthylene diisocyanate
- Cas Number:
- 3173-72-6
- Molecular formula:
- C12H6N2O2
- IUPAC Name:
- 1,5-diisocyanatonaphthalene
- Details on test material:
- no further information
Constituent 1
Method
- Type of population:
- occupational
- Controls:
- no data
- Route of administration:
- inhalation
Results and discussion
Any other information on results incl. tables
2/3 patients with occupationally related asthma had non-immediate reactions by exposure to NDI only; 1/3 of the same patients had a
dual reaction provoked by NDI (no reaction to MDI, TDI and exercise).
Applicant's summary and conclusion
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