Registration Dossier
Registration Dossier
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EC number: 221-641-4 | CAS number: 3173-72-6
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Based on the calculated log Kow of 4.37, a BCF of about 354 for 1,5 -naphthalene diisocyanate is estimated using the EPI Suite program, v. 4.0. (Currenta, 2010). As 1,5 -naphthalene diisocyanate hydrolysis with a half-life time of less than 1 hour in aquatic media, the estimated BCF is only of theoretical interest. The bioconcentartion factor (BCF) of the hydrolysis product 1,5-naphthylene diamine in carp (Cyprinus carpio) was determined by the Chemicals Inspection & Testing Institute of Japan (MITI, 1992). The test was conducted in accordance with "Bioaccumulation test of chemical substance in fish and shellfish", which corresponds to the OECD TG 305C, "Bioaccumulation: Degree of bioconcentration in fish", 1981. The fish were exposed to concentrations of 0.2 mg/l and 0.002 mg/l. A BCF of < 4.5 at the low concentration and a BCF <0.4 - 1.5 at the higher concentration were obtained.
Key value for chemical safety assessment
- BCF (aquatic species):
- 4.5 dimensionless
Additional information
The key value should read < 4.5.
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