Registration Dossier
Registration Dossier
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EC number: 604-075-6 | CAS number: 138401-24-8
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995-10-22 to 1996-03-29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test follows standard guideline. Conducted under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- [1,1’-Biphenyl]-2-carbonitrile, 4’-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-
- IUPAC Name:
- [1,1’-Biphenyl]-2-carbonitrile, 4’-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-
- Reference substance name:
- 4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-ene-3-yl)methyl)(1,1'-biphenyl)-2-carbonitrile
- EC Number:
- 604-075-6
- Cas Number:
- 138401-24-8
- Molecular formula:
- C25H27N3O
- IUPAC Name:
- 4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-ene-3-yl)methyl)(1,1'-biphenyl)-2-carbonitrile
- Details on test material:
- - Name of test material (as cited in study report): SR 47563
- Physical state: beige powder
- Lot/batch No.: 5 ARL 005
- Analytical purity: 96.8 %
- Storage condition of test material: dans un récipient fermé à l'abri de la chaleur dans un endroit ventilé.
Constituent 1
Constituent 2
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 3.7
- Temp.:
- 20 °C
- pH:
- 7
Any other information on results incl. tables
Method chosen after preliminary test : HPLC method.
Analytical method used: Liquid chromatography. UV detection. Measured values match in a +/- 0.1 log unit interval.
Applicant's summary and conclusion
- Conclusions:
- Under the test conditions logKow of the substance is 3.7
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