Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 939-967-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
1. Information on zirconium dioxide (CAS# 1314-23-4)
Acute toxicity: oral
The LD50-value for acute oral toxicity determined via the acute class method in female Sprague-Dawley rats was > 5000 mg/kg.
2. Information on erbium oxide (CAS# 12061-16-4)
The oral LD50 of the test material was > 2000 mg/kg in rats. No signs of toxicity were observed at this dose.
3. Conclusion on erbium zirconium oxide
It is expected that the substance will have a similar toxicity profile as the read across substances zirconium dioxide and erbium oxide, more specifically that it is not expected to cause any adverse acute toxic effects after oral intake.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
1. Information on zirconium dioxide (CAS# 1314-23-4)
Acute toxicity: oral
One key study was identified. Acute toxicity was determined via the acute class method (OECD Guideline 423 and EU Method B1 tris) in female Sprague-Dawley rats. The LD50 value was > 5000 mg/kg.
2. Information on erbium oxide (CAS# 12061-16-4)
Acute toxicity: oral
The acute oral toxicity of erbium oxide was evaluated in a limit test which was conducted in accordance with the standardised guideline OECD 401. Groups of fasted, 6 week old Sprague-Dawley rats (5 per sex) were given a single oral dose of the test material in an aqueous solution of methylcellulose at 0.5 % at a dose of 2000 mg/kg bw (dose volume 10 mL/kg) and observed for 14 days. No mortality and no clinical signs were observed during the study. The body weight gains of the treated rats were normal. No gross abnormalities were observed at necropsy. The oral LD50 (males and females) was >2000 mg/kg bw and therefore the test material is not classified for acute oral toxicity in accordance with EU criteria.
3. Conclusion on erbium zirconium oxide
It is expected that the substance will have a similar toxicity profile as the read across substances zirconium dioxide and erbium oxide, more specifically that it is not expected to cause any adverse acute toxic effects.
Justification for classification or non-classification
1. Information on zirconium dioxide (CAS# 1314-23-4)
- Based on the available data and according to the DSD/CLP criteria zirconium dioxide should not be classified for acute toxicity via the oral route of exposure.
- No reliable data are available on the acute toxicity via the dermal route of exposure. Therefore no conclusion can be made on the classification for this exposure route.
- Based on available data (not included in this dossier, second route is not an Annex VII requirement) zirconium dioxide should not be classified for acute toxicity via the inhalation route of exposure.
2. Information on erbium oxide (CAS# 12061-16-4)
- Based on the available data and according to the DSD/CLP criteria erbium oxide should not be classified for acute toxicity via the oral route of exposure.
- No data are available on the acute toxicity via the dermal route of exposure. Therefore no conclusion can be made on the classification for this exposure route.
- Based on available data (not included in this dossier, second route is not an Annex VII requirement) erbium oxide should not be classified for acute toxicity via the inhalation route of exposure.
3. Conclusion on erbium zirconium oxide
As erbium zirconium oxide is expected to have similar properties as the read across substances zirconium dioxide and erbium oxide, it does not need to be classified as acutely toxic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

Route: .live1