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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1992
Reference Type:
secondary source
Title:
SIDS Category of Alkyl sulfates, Alkane sulfonates and Alpha-olefin sulfonates
Author:
OECD
Year:
2007
Bibliographic source:
UNEP Publications

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
Deviations:
yes
Remarks:
Only limited data on test item and methodology available
Principles of method if other than guideline:
Method: other
GLP compliance:
yes
Type of study:
mouse local lymph node assay (LLNA)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (cited in study report): No data
- Physical state: No data
- Analytical purity: 31.7% a.i.
- Lot/batch No.: No data
- Storage condition of test material: No data

In vivo test system

Test animals

Species:
mouse
Strain:
CBA
Sex:
female

Study design: in vivo (LLNA)

Vehicle:
other: water
Concentration:
12.5 µl of a 10, 50 or 100% solution
No. of animals per dose:
5

Results and discussion

In vivo (LLNA)

Results
Parameter:
SI
Remarks on result:
other: 1.25, 2.7 or 3.1

Any other information on results incl. tables

The treatment had no significant effect on thymidine incorporation by 

auricular lymph node cells when compared with naive and carrier controls:

stimulation index: 1.25, 2.7 or 3.1
naive control: 2.4
carrier control: 1

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU