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EC number: 939-606-3 | CAS number: 96690-74-3
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
42d NOEC (Pimephales promelas; mortality and growth) >= 1.357 mg/L (measured concentration)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.357 mg/L
Additional information
Since no reliable chronic fish test is available for C8-14AS NH4 & TEA (CAS 96690-74-3), in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5, a read-across to other structurally related category members was conducted. Read-across data from C12AS Na (CAS 151-21-3) and C14-15AS Na (CAS 68081-98-1) were used.
A 42-day flow-through study with fathead minnow (Pimephales promelas) examining the toxic effect of CAS 151-21-3 is available (Belanger et al. 1995). Juvenile mortality and juvenile growth were determined in a non-GLP test after exposure to five concentrations up to 1.357 mg/L (measured concentration, equal to 2.1 mg/L of nominal concentration). Since no adverse effects were observed regarding fish survival and body weight, the NOEC value was determined as equal as or higher than 1.357 mg/L (measured concentration). The toxicity pattern observed for the alkyl sulfate category confirms that the toxic effects increase with the increasing carbon chain, the most toxic at C14-15. It is therefore expected that the toxicity of C8-14AS NH4 & TEA (CAS 96690-74-3) will be comparable to the tested category member C12AS Na (CAS 151-21-3).
In two further studies fathead minnows (Pimephales promelas) were exposed to C14 -15AS Na (CAS 68081-98-1) which is considered as the worst case mixture for the whole alkyl sulfate category. In the non-GLP study of Sousa (1987), which was conducted equivalent to OECD 210 guideline, fathead minnow was exposed to C14-15AS over 34 days in a flow-through system. The highest test concentration was 4.3 mg a.i./L (measured concentration equal to 6.0 mg a.i./L of nominal concentration). The early-life stage test resulted in the lowest NOEC-value of 0.11 mg a.i./L (measured concentration) for larvae survival. This result by Sousa corresponds well with the NOEC-value determined in a GLP-study of Versteeg and Rawlings (1997). In this test fathead minnows (Pimephales promelas) were exposed with the same C14-15AS Na mixture (56% C14 and 44% C15) in an outdoor flow-through system over 35 days. The exposure method is described as equivalent to OECD 53, guidance on simulated freshwater lentic field tests. The resulting NOEC-value is reported to be 0.371 mg/L for growth (length and weight). It can be expected that the toxicity of C14-15AS is much higher than of C8-14AS NH4 & TEA (CAS 96690-74-3). C8-14AS NH4 & TEA (CAS 96690-74-3) contains on average 14.1% of C8, 14.1% of C10, 46.9% of C12 and 24.9% of C14, no carbon chains above C14 are present.
It can be concluded that the reliable NOEC value of C8-14AS NH4 & TEA (CAS 96690-74-3) for fish is equal as or higher than 1.357 mg/L.
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