Registration Dossier
Registration Dossier
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EC number: 221-304-1 | CAS number: 3061-75-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No effect up to the limit of the water solubility was observed. Thus, the EC50 exceeds the water solubility of the test substance. The test substance is not harmful to algae.
Key value for chemical safety assessment
Additional information
The hazard assessment is based on the data currently available. This information will be submitted later based on ECHA communication/decision number TPE/CCH-D-2114598209-34-01/F
No data are available for the toxicity of docosanamide (CAS No. 3061-75-4) towards aquatic algae. Therefore data from the analogue substance (Z) -docos-13-enamide (CAS No.112-84-5) and amides, C16-18 even numberedwere used as read across.
The influence of the test item (Z)-Docos-13-enamide on the growth of the freshwater green algal species Pseudokirchneriella subcapitata was investigated in a 72-hour static test according to OECD Guideline 201 (2006). The nominal concentrations of the test item of 4.6, 10, 22, 46 and 100 μg/L were tested. The highest test concentration of 100 μg/L lies clearly above the water solubility limit of the test item. The test item (Z)-Docos-13-enamide had no biologically relevant inhibitory effects on the algal growth (average growth rate and yield) up to the highest test concentration.
A second GLP guideline study according to OECD 201 is available for amides, C16-18 even numbered. In the 72 hour algae study with Desmodesmus subspicatus no effects on growth rate were observed to an initial measured test concentration of 0.17 mg/L, the highest attainable concentration. This study showed that there were no toxic effects at saturation. The test substance is not harmful to algae.
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