Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
nanomaterial aspect ratio/shape
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2019
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
other: unpublished study report
Title:
Unnamed
Year:
2019
Report date:
2019

Materials and methods

Principles of method if other than guideline:
Method selection according to Gaillard et al., Nanoscale Adv., 2019, 1, 781
GLP compliance:
no
Type of method:
transmission electron microscopy
Details on methods and data evaluation:
TEM image evaluation according to Verleysen et al., Materials 2019, 12, 2274; doi:10.3390/ma12142274.
Sample Preparation: Intertek.

Test material

1
Reference substance name:
-
EC Number:
440-560-7
EC Name:
-
Cas Number:
346709-25-9
Molecular formula:
Unspecified
IUPAC Name:
2,6,8-triamino-4H,10H-pyrimido[5,4-g]pteridin-4-one; pyrimido[5,4-g]pteridine-2,4,6,8-tetramine
Test material form:
solid: nanoform

Data gathering

Instruments:
TEM: Intertek

Results and discussion

Shape description
Key result
Shape:
rod
Remarks on result:
other: The material is assigned to the “elongated” shape category.
Aspect ratio
Key result
x Dimension:
2.4
St. dev.:
1.4
y Dimension:
1
Remarks on result:
other: median (D50)

Any other information on results incl. tables

The number-based concentration of particles with sizes below 100 nm (smallest feret diameter) is 78%. The median (D50) of the particle size is 67,6 nm.
The material is therefore classified as “nano” according to the definition of nanomaterial 2011/696/EU.

Applicant's summary and conclusion

Conclusions:
- The particles have a median aspect ratio of 2,4:1.
- The shape is “rod”. The material is assigned to the “elongated” shape category.
- The number-based concentration of particles with sizes below 100 nm (smallest feret diameter) is 78%. The median (D50) of the particle size is 67,6 nm.
The material is therefore classified as “nano” according to the definition of nanomaterial 2011/696/EU.