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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1967
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: short summary, non GLP, no guideline followed

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1967
Report Date:
1967

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
4 h whole body exposure to an unknown air concentration of the test substance.
GLP compliance:
no
Remarks:
Study performed prior to implementation of GLP
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: rats (wistar) and guinea pig
Sex:
female
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
air
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION

- Exposure chamber volume: 28 L
- Method of conditioning air: 24.5 g of the product was vapoured at 125-130°C, Airflow: 500 liter/hour
- Temperature in air chamber: 29°C
Duration of exposure:
4 h
Concentrations:
less than 1.2 mg/L, exact concentration unknown (the evaporated test item recrystallised partly before the vapour reached the inhalation chamber)
No. of animals per sex per dose:
5 rats and 5 guinea pigs
Details on study design:
- Duration of observation period following administration: 7 days

Results and discussion

Effect levels
Key result
Sex:
female
Dose descriptor:
LC0
Effect level:
> 0.9 - < 1.2 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: rats and guinea pigs were tested; actual exposure concentration unknown as the evaporated test item recrystallised partly before the vapour reached the inhalation chamber
Mortality:
no
Clinical signs:
other: no
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

Based on the equation for saturated vapour concentrations it can be estimated that the concentration of the substance is approx. 0.88 mg/L saturated air at 20 °C. Therefore, it is assumed that at a temperature of 29 °C the test item concentration was between 0.88 and 1.2 mg/L.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
Under the conditions of the present acute toxicity study the inhalation of the test item crotonic acid showed no abnormal behaviour in rats and guinea pigs.