Registration Dossier
Registration Dossier
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EC number: 939-705-1 | CAS number: 2867-59-6
Endpoint summary
Administrative data
Description of key information
LD50(oral,rat): > 300 <2000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 300 mg/kg bw
- Quality of whole database:
- The LD50 was between >300 <2000 mg/kg bw.
Additional information
Acute oral
In an acute oral toxicity study performed according to the Acute Toxic Class method (OECD 423), doses of 2000 and 300 mg/kg bw of the test item 3-Amino-butan-1-ol (undiluted or preparations in deionized water) were administered by gavage to three test groups of three fasted Wistar rats each (2000 mg/kg bw in 3 females, 300 mg/kg bw in 6 females). All animals of the 2000 mg/kg bw test group died at hour 5 or on study day 1 or 2. No mortality occurred in both 300 mg/kg bw test groups. Clinical findings in the 300 mg/kg bw test group were impaired general state, dyspnoea, piloerection, reduced defecation, gasping. There were no macroscopic pathological findings in the surviving animals of both 300 mg/kg test groups sacrificed at the end of the observation period. The acute oral LD50 was calculated to be LD50, oral, rat > 300 < 2000 mg/kg bw. [BASF, 2014]
Justification for selection of acute toxicity – oral endpoint
only one study available
Justification for classification or non-classification
EU classification according to Annex I of Directive 67/548/EEC: Xn, R22
According to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 subtance is classified as Cat. 4 harmful if swallowed
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