Registration Dossier

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

A study according to OECD 211 is technically not feasible due to substance characteristics.

Key value for chemical safety assessment

Additional information

No experimental studies investigating the long-term toxicity of 2-octyldodecyl isooctadecanoate (CAS 93803-87-3) to aquatic invertebrates are available. A statement from a laboratory is available indicating that the study is technically not feasible due to substance characteristics (Bogers, 1998). Acute testing in Daphnia magna was performed by exposing organisms to Water Accommodated Fractions (WAFs). However, it is not common practice to use this approach in a prolonged toxicity test. The use of a column generator with the test substance coated on an inert carrier (glass beads or celite) is not possible as the test substance is a liquid. The testing in a flow-through system is also no possible alternative, since the hydrophobic character of the test substance hampers any way of mixing with the dilution water. Based on the high hydrophobicity, there is no analytical method sensitive enough to detect concentrations of the test substance in water samples. As a result, it is not possible to give any analytical support to the reproduction test with Daphnia magna. This analytical support is essential to meet the acceptability criterion for evidence that the actual concentration had been maintained within a 20% window during the total test period.

Owing to the fact that the test substance is a liquid with water solubility below detection limit (< 0.05 mg/L) and a log Kow of > 7, it is not possible to prepare solutions that can be tested in a 21-day reproduction test with Daphnia magna. Further, these characteristics support the expectation that it will not be very likely that bioavailable concentrations of the test substance will ever occur in the water phase, i.e. concentrations high enough to induce any acute or chronic effects in aquatic organisms. Thus, no chronic test with aquatic invertebrates was conducted.