Registration Dossier
Registration Dossier
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EC number: 242-053-4 | CAS number: 18169-57-8
Endpoint summary
Administrative data
Description of key information
There are no data for skin and eye irritation/corrosion. However, based on the fact that this substance is a chlorosilane, so generates hydrogen chloride in the presence of moisture, it is expected to be corrosive. Therefore, in accordance with Column 2 of REACH Annex VIII, the in vivo skin irritation study and eye irritation study (required in Section 8.1.1 and 8.2.1) do not need to be conducted as the available information indicates that the substance meets the criteria for classification as corrosive to skin.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Trichloroisobutylsilane hydrolyses rapidly (half-life <1 minute at pH7) in contact with water and moist air, releasing 3 moles of hydrogen chloride (HCl) for each mole of parent material. Although no reliable in vivo irritation/corrosion studies are available, severe skin, eye and respiratory damage can be expected due to release of HCl. This is consistent with reliable measured data for other chlorosilanes.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Effects on respiratory irritation: highly irritating
Justification for classification or non-classification
Trichloroisobutylsilane is labelled 'R35 Causes severe burns' according to the criteria of EU Directive 67/548/EEC, and 'Skin Corr. 1A' under Regulation 1272/2008. It is assumed that substances that are corrosive to the skin are also damaging to the eyes, so there is no separate labelling for the eyes.
Consistent with other chlorosilanes, the additional classification EUH017 "Corrosive to respiratory tract" is also proposed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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