Registration Dossier

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Materials and methods

Principles of method if other than guideline:
other: systemic effects after i.p. application in mice
GLP compliance:
no

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Doses:
no data
No. of animals per sex per dose:
27 (total number)
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
200 mg/kg bw

Applicant's summary and conclusion

Conclusions:
Thioglycolate poisoning is characterized by a prolonged period of depression. Animals given fatal doses usually died between 12 and 36 hours after injection.