Registration Dossier
Registration Dossier
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EC number: 618-460-1 | CAS number: 9010-89-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Two acute toxicity studies are available for the test substance Hexanedioic acid, polymer with 2,2'-oxybis[ethanol]: an oral study according to OECD Guideline 423 and a dermal study according to OECD Guideline 402.
In the acute oral toxicity study, 2000 mg/kg of the undiluted test item Polyesterol 90212 were administered by gavage to two test groups of three fasted Wistar rats each (females). Mortality did not occur in any of the test groups, and no pathological findings were recorded. Clinical signs occuring within the first 2 hours after administration were observed in the first test group only and included impaired general state and piloerection. The second test group was free of clinical signs. Stagnation of body weights was observed in both groups in the second week. The acute oral LD50 was calculated to be > 2000 mg/kg bw.
In an acute dermal toxicity study, young adult Wistar rats (5 males and 5 females) were exposed to a single dose of 2000 mg/kg bw of Polyesterol 90212 (undiluted) to the clipped skin and covered by semi-occlusive dressing for 24 hours. The animals were observed for 14 days. No signs of systemic toxicity or mortality were observed in the animals.
The only test item-related local effect was very slight (grade 1) erythema in two animals, occuring within the first two days after administration. The acute dermal LD50 was determined to be > 2000 mg/kg bw.
Justification for classification or non-classification
Based on the available information, classification according to Regulation (EC) 1272/2008 and Directive 65/548/EEC is not warranted.
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